-
Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis
Jin W, Zhang T, Zhou W, He P, Sun Y, Hu S, Chen H, Ma X, Peng Y, Yi Z, Liu M, Chen Y.（2022）
J Med Chem.65(9), 6710–6728.
-
PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis
Jiang, W., Jin, Y., Zhang, S., Ding, Y., Huo, K., Yang, J., Zhao, L., Nian, B., Zhong, T. P., Lu, W., Zhang, H., Cao, X., Shah, K. M., Wang, N., Liu, M., & Luo, J. (2022)
Bone research, 10(1), 27
-
Single-Cell Analysis Reveals EP4 as a Target for Restoring T-Cell Infiltration and Sensitizing Prostate Cancer to Immunotherapy
Peng S, Hu P, Xiao YT, Lu W, Guo D, Hu S, Xie J, Wang M, Yu W, Yang J, Chen H, Zhang X, Zhu Y, Wang Y, Yang Y, Zhu G, Chen S, Wang J, Zhang B, Chen W, Wu H, Sun Z, Ding T, Zhang H, Yi Z, Liu M, Ren S. (2022).
Clinical cancer research, 28(3), 552–567.
-
A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration
Jin, Y., Liu, Q., Chen, P., Zhao, S., Jiang, W., Wang, F., Li, P., Zhang, Y., Lu, W., Zhong, T. P., Ma, X., Wang, X., Gartland, A., Wang, N., Shah, K. M., Zhang, H., Cao, X., Yang, L., Liu, M., & Luo, J. (2022).
Cell discovery, 8(1), 24
-
A Novel Small Molecular Prostaglandin Receptor EP4 Antagonist, L001, Suppresses Pancreatic Cancer Metastasis
He, J., Lin, X., Meng, F., Zhao, Y., Wang, W., Zhang, Y., Chai, X., Zhang, Y., Yu, W., Yang, J., Li, G., Du, X., Zhang, H., Liu, M., & Lu, W. (2022)
Molecules, 27(4), 1209
-
Targeting STAT3 by a small molecule suppresses pancreatic cancer progression
Chen, H., Bian, A., Yang, L. F., Yin, X., Wang, J., Ti, C., Miao, Y., Peng, S., Xu, S., Liu, M., Qiu, W. W., & Yi, Z. (2021)
Oncogene, 40(8), 1440–1457
-
Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer
Lu W, Yu W, He J, Liu W, Yang J, Lin X, Zhang Y, Wang X, Jiang W, Luo J, Zhang Q, Yang H, Peng S, Yi Z, Ren S, Chen J, Siwko S, Nussinov R, Cheng F, Zhang H, Liu M. (2021)
EMBO Mol Med, 13(1), e12798
-
Discovery and Characterization of 1H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy
Yang, J. J., Yu, W. W., Hu, L. L., Liu, W. J., Lin, X. H., Wang, W., Zhang, Q., Wang, P. L., Tang, S. W., Wang, X., Liu, M., Lu, W., & Zhang, H. K. (2020)
J Med Chem, 63(2), 569–590
-
Recent Advances of Small Molecular Regulators Targeting G Protein- Coupled Receptors Family for Oncology Immunotherapy
He P, Zhou W, Liu M, Chen Y. (2019)
Curr Top Med Chem, 19(16):1464-1483
